Merkel cell carcinoma of the skin. Treatment of primary, recurrent and metastatic disease: review of clinical cases
Queirolo, P.; Gipponi, M.; Peressini, A.; Raposio, E.; Vecchio, S.; Guenzi, M.; Sertoli, M.R.; Santi, P.; Cafiero, F.
Anticancer Research 17(3c): 2339-2342
1997
ISSN/ISBN: 0250-7005 PMID: 9216711 Document Number: 470341
The clinical features of 10 cases of primary neuroendocrine carcinoma of the skin (Merker cell tumor) are reported. This cancer arises in the dermis and subcutaneous tissues of elderly individuals. Natural history is characterized by local recurrences (30%), regional lymph node metastases (65%) and distant metastases (40%). Surgery is elective treatment, chemotherapy and radiotherapy resulted only to short-term palliative response.