Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases
Makino, T.; Tsujinaka, T.; Mishima, H.; Ikenaga, M.; Sawamura, T.; Nakamori, S.; Fujitani, K.; Hirao, M.; Kashiwazaki, M.; Masuda, N.; Takeda, M.; Mano, M.
Hepato-Gastroenterology 53(72): 845-849
2006
ISSN/ISBN: 0172-6390 PMID: 17153438 Document Number: 600391
Background/Aims: Primary signet-ring cell colorectal carcinoma is rare and has been reported to have an extremely poor prognosis. The purpose of the present study was to define the characteristics of this cancer.Methodology: Clinicopathological features were analyzed in 154 Japanese patients.Results: The mean age at diagnosis was 54.3 years. The most common tumor site was the rectum (32.9%). Frequent type of the tumor was scirrhous in 45.8%, ulcerated in 34.5%. Lymph node metastasis was found in 77.4% and synchronous peritoneal dissemination was seen in 38.7%, while synchronous liver metastasis was only detected in 2.9%. Most patients (78.2%) were in stages III or IV. The overall median survival time was 12.7 months and the 5-year survival rate was 9.4%. For stage II patients, the median survival time and 5-year survival rate were 17.4 months and 14.3%, respectively, while the median survival time was 15.4 months in stage Ill and 7.9 months in stage IV. The 5-year survival rate of patients with T2 disease was 75.0%, while patients with T3 or T4 had survival rates of 5.1% and 0%, respectively.Conclusions: Since the prognosis of primary signet-ring cell colorectal carcinoma is extremely poor, early diagnosis and aggressive treatment strategy are necessary.
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