Natural immunity and herpes infection
Lavrov, V.F.; Koval'chuk, L.V.; Gankovskaia, L.V.; Barkevich, O.A.; Kuzin, S.N.
Voprosy Virusologii 51(3): 4-9
2006
ISSN/ISBN: 0507-4088 PMID: 16826749 Document Number: 600392
The review details natural immunological factors that are the first-line protection from herpes simplex virus. These reactions may be conventionally divided into 3 active phases. In Phase 1, the virus is attacked by proteins, such as complement of precursors of natural class M (IgM) antibodies and antimicrobial peptides. In Phase 2 the interferons produced by infected epithelial and resident dendritic cells go into action. And, finally, in Phase 3, effector cells, such as neutrophils, macrophages, and natural killer cells, show antiviral. activity.
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