Merkel cell carcinoma: clinical characteristics, markers, staging and treatment
Lien, M.H.; Baldwin, B.T.; Thareja, S.K.; Fenske, N.A.
Journal of Drugs in Dermatology Jdd 9(7): 779-784
2010
ISSN/ISBN: 1545-9616 PMID: 20677532 Document Number: 13531
Merkel cell carcinoma (MCC) is a highly aggressive neoplasm affecting primarily the elderly Caucasian population. Earlier detection of this neoplasm may achieve a better prognosis and an improved outcome. Here, the authors review the typical clinical features of MCC to serve as a reference tool for clinicians in determining when a biopsy may be warranted. An array of immunohistochemical markers may be utilized to differentiate MCC from other neuroendocrine tumors. The staging and concomitant treatment options of MCC are discussed. In addition, the authors review therapeutic advances for treatment of MCC utilizing an array of target proteins.
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