Levels of lactic acid in type Ii diabetics treated with buformin
Perusicová, J.; Skrha, J.; Hodinár, A.; Bernovská, A.; Cacáková, V.; Richtrová, A.
Vnitrni Lekarstvi 42(1): 7-11
1996
ISSN/ISBN: 0042-773X PMID: 8629364 Document Number: 468229
The objective of the work was to assess the blood lactate levels in type 2 diabetics selected at random, treated for prolonged periods with buformin. 77% of the investigated group of diabetics (N = 70) had elevated blood lactate levels and 16% of them had hyperlactataemia (more than 5.0 mmol/l). In 33% patients with an originally elevated lactataemia after 12 weeks of discontinued buformin treatment the lactic acid blood levels reached normal values. The lactate levels declined significantly (by more than 25% of the original value) after 6 weeks without buformin treatment in another 45% of the diabetic patients. In 18% of the investigated patients, who had high lactate levels even after discontinuation of treatment, in two-thirds neither impaired function of the kidneys and liver nor cardiac disease or alcoholism were detected.