Evaluation of blood compatibility of surface modification treated poly (D, L-lactic and glycolic acid) with mPEG block copolymer
Nie, Y.; Duan, Y.; Zhang, Z.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 24(2): 336-339
2007
ISSN/ISBN: 1001-5515 PMID: 17591255 Document Number: 606971
To identify the advantages of modification treated poly (D, L-lactic and glycolic acid) with poly (ethylene glycol) (PLGA/mPEG, PELGA) block copolymer, blood compatibility was evaluated in vitro. Three different proportional block copolymers (LA/GA80: 20, 70: 30, 50: 50) with 15% mPEG were synthesized. According to the international standard organization (ISO10993) and National Standards of P. R. China GB/T 16886, siliconized glass tube was used as a negative control sample, while non-siliconized glass tube as a positive one. Blood compatibility of PELGA was evaluated by hemolytic ratio analysis, platelet adhesion investigation, dynamic clotting time, plasma recalcification time (PRT) measurements, plasma prothrombin time (PT) and clotting time (CT) test. The results revealed that blood compatibility of the synthesized materials was good. Nanoparticles made by this kind of materials might be promising for intravenous use.