Histological evaluation of domestic poly-DL-lactic acid membranes for periodontal guided tissue regeneration
Yin, Y.-z.; Shu, R.; Liu, X.-f.; Liu, Z.
Shanghai Kou Qiang Yi Xue 11(2): 125-128
2002
ISSN/ISBN: 1006-7248 PMID: 14983292 Document Number: 545631
To evaluate the possibility of domestic poly-DL-lactic acid membranes as barriers during periodontal guided tissue regeneration. Two-wall intrabony defects were made by artificially removing buccal and distal alveolar bone from the distal roots of the second, third and fourth mandibular premolars as well as the first mandibular molars of dogs. These experiment defects received four membranes (PDLLA, ePTFE, COL, Vicryl ) respectively for GTR, the control treated without membrane. Animals were sacrificed for histological evaluation and histometric analysis 2,4,8 weeks after surgery. Domestic poly-DL-lactic acid membranes for periodontal guided tissue regeneration only induce a non-specific inflammation, which began its bioresorption at 4 weeks after surgery. Just like the other GTR materials including Vicryl mesh,domestic poly-DL-lactic acid membrane acts as barrier preventing the apical downgrowth of gingival epithelium and prompting periodontal tissue regeneration. As compared with the control, PDLLA exhibited its more effects 4 weeks after surgery, there is statistically difference between them. Domestic poly-DL-lactic acid membranes exhibit excellent biocompatibility, as a guided tissue regenerative materials, it may have beneficial effects in the treatment of 2-wall periodontal intrabony defects.