Investigation on in vivo metabolism of n-butyl phthalide
Peng, S.H.; Zhou, T.H.
Yao Xue Xue Bao 31(10): 780-784
1996
ISSN/ISBN: 0513-4870 PMID: 9863247 Document Number: 463561
A GC-MS method for the investigation on the metabolism of n-butyl phthalide (NBP) is described. After oral administration of NBP to rats, urine was collected, hydrolyzed with beta-glucuronidase, extracted and concentrated for TMS derivatization, and then analyzed by GC-MS. HBP and its four oxidative metabolites were determined in 0 apprx 24 h, 24 apprx 48 h rat urine. The mass spectra of the metabolites and their derivatives were presented and the in vivo metabolic pathway was discussed.
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