Investigation of the bioadhesion of carbopol and hydroxypropyl methylcellulose to rat gastrointestinal mucosa in vivo and in vitro
Zhang, Z.R.; Fu, J.; Huang, Y.; Duan, Y.S.
Yao Xue Xue Bao 36(7): 543-546
2001
ISSN/ISBN: 0513-4870 PMID: 12585090 Document Number: 531508
To investigate bioadhesion of carbopol and hydroxypropyl methylcellulose of different viscosity grade to rat gastrointestinal mucosa. The maximum adhesion force has been adopted as an index of adhesive evaluation in vitro, gastro-emptying rate and migrating length in intestine have been adopted as an index of adhesive evaluation in vivo. In vitro adhesion studies indicated that the adhesive force of low-vicosity materials was stronger than that of high-vicosity materials, while the transferation rate of high-vicosity materials is significantly higher compared to that of low-vicosity materials in vivo. Adhesive force of materials gives no correlation with rate of the materials in rat; Cb934 have the optium bioadhesion among the studied materials and can be used as the preferred adjuvant in oral bioadhesion preparation.