The protective effect of 3-butyl phthalide on rat brain cells
Yu, S.R.; Gao, N.N.; Li, L.L.; Wang, Z.Y.; Chen, Y.; Wang, W.N.
Yao Xue Xue Bao 23(9): 656-661
1988
ISSN/ISBN: 0513-4870 PMID: 3256199 Document Number: 321883
3-Butyl phthalide was found to have anticonvulsant activity in animal experiments. In the present study, a model of chronic epilepsy was induced by im coriaria lactone 0.9 .apprx. 1.5 mg/kg in rats for 3 months. Ag-1 700 mg/kg ig was shown to prolong the latent period of the epileptic seizures, reduce the severity of the seizures and the number of animals with seizures. Of particular importance is the fact that, no evidence of lesions in the cerebral neurons, glial cells and cerebellar Purkinje's of the Ag-1 treated animals was observed in histological studies. This result is especially encouraging as Ag-1 may have a protective effect on rat brain cells.