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Exploitation of the Vbeta8.2 T cell receptor in protection against experimental autoimmune encephalomyelitis using a live vaccinia virus vector

Chunduru, S.K.; Sutherland, R.M.; Stewart, G.A.; Doms, R.W.; Paterson, Y.

Journal of Immunology 156(12): 4940-4945

1996

ISSN/ISBN: 0022-1767
PMID: 8648145
Document Number: 462568
This study takes advantage of the predominant usage of V-beta-8.2 by the TCRs of encephalitogenic T cells specific for myelin basic protein. Vaccinia virus recombinants expressing V-beta-8.2 (VV-beta-8.2) and V-beta-3 (VV-beta-3) proteins were constructed, and their abilities to confer protection against experimental autoimmune encephalomyelitis (EAE) induction in H-2-u mice were examined. Mice immunized with VV-beta-8.2 developed very mild EAE by comparison with mice that were vaccinated with VV-beta-3, which developed severe clinical symptoms. This reduction in EAE correlated with a diminished T cell proliferative response to myelin basic protein in the mice that received VV-beta-8.2 compared with that in mice receiving VV-beta-3.

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Ben-Nun, A.; Lando, Z. 1983: Detection of autoimmune cells proliferating to myelin basic protein and selection of T cell lines that mediate experimental autoimmune encephalomyelitis (EAE) in mice Journal of Immunology 130(3): 1205-1209
Sviatchenko, V.A.; Agapov, E.V.; Urmanov, I.Kh.; Serpinskiĭ, O.I.; Frolov, I.V.; Kolykhalov, A.A.; Ryzhikov, A.B.; Netesov, S.V. 1993: The immunogenic properties of a recombinant vaccinia virus with an incorporated DNA copy of the 26S RNA of the Venezuelan equine encephalomyelitis virus Voprosy Virusologii 38(5): 222-226
Wojcik, J. 1995: Expression of feline immunodeficiency virus (FIV) gag gene in vaccinia virus vector Acta Microbiologica Polonica 44(2): 191-196
Beaud, G.; Mars, M.; Vassef, A. 1987: Vaccinia virus as a vector Developments in Biological Standardization 66: 49-54
Frankel, F.R.; Hegde, S.; Lieberman, J.; Paterson, Y. 1995: Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector Journal of Immunology 155(10): 4775-4782
Stefferl, A.; Brehm, U.; Storch, M.; Lambracht-Washington, D.; Bourquin, C.; Wonigeit, K.; Lassmann, H.; Linington, C. 1999: Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response Journal of Immunology 163(1): 40-49
Lobashevsky, A.; Kotb, M.; Gaber, A.O. 1996: Selective T cell receptor Vbeta gene usage by alloreactive T cells responding to defined HLA-DR alleles Transplantation 62(9): 1332-1340
Chen, J.-y.; Liu, W.-w.; Chen, L.-z.; Zhan, Y.; Chen, S.-h.; Yang, L.-j.; Li, Y.-q. 2006: Expression of T cell receptor Vbeta subfamily gene in patients with benzene-induced aplastic anemia Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24(1): 59-60
Heber-Katz, E. 1991: The autoimmune T-cell receptor in experimental disease Immunology Series 55: 155-169
Nicholas, R.A.; Hopkins, I.G.; Southern, S.J.; Thornton, D.H. 1986: A comparison of titration methods for live avian encephalomyelitis virus vaccines Developments in Biological Standardization 64: 207-212
Deshmukh, D.R.; Larsen, C.T.; Rude, T.A.; Pomeroy, B.S. 1973: Evaluation of live-virus vaccine against avian encephalomyelitis in turkey breeder hens American Journal of Veterinary Research 34(7): 863-867
Marcelino, J.é M.; Borrego, P.; Rocha, C.; Barroso, H.; Quintas, A.; Novo, C.; Taveira, N. 2010: Potent and broadly reactive HIV-2 neutralizing antibodies elicited by a vaccinia virus vector prime-C2V3C3 polypeptide boost immunization strategy Journal of Virology 84(23): 12429-12436
Mackay, I.R.; Carnegie, P.R.; Coates, A.S. 1973: Immunopathological comparisons between experimental autoimmune encephalomyelitis and multiple sclerosis Clinical and Experimental Immunology 15(4): 471-482
Dittel, B.N. 2000: Evidence that Fas and FasL contribute to the pathogenesis of experimental autoimmune encephalomyelitis Archivum Immunologiae et Therapiae Experimentalis 48(5): 381-388
Moore, G.R.; Traugott, U.; Farooq, M.; Norton, W.T.; Raine, C.S. 1984: Experimental autoimmune encephalomyelitis. Augmentation of demyelination by different myelin lipids Laboratory Investigation; a Journal of Technical Methods and Pathology 51(4): 416-424
Kawai, K.; Kobayashi, Y.; Miyasaka, M.; Yoshikai, Y.; Sobue, G. 1995: Suppression of experimental autoimmune encephalomyelitis with antibodies against adhesion molecules Rinsho Shinkeigaku 35(12): 1504
Javed, N.H.; Gienapp, I.E.; Cox, K.L.; Whitacre, C.C. 1995: Exquisite peptide specificity of oral tolerance in experimental autoimmune encephalomyelitis Journal of Immunology 155(3): 1599-1605
Lifson, J.D.; Oyasu, R.; Dreyer, N.; Carone, F.A.; Williams, R.M. 1983: Acute hemorrhagic obstructive uropathy as a complication of experimental autoimmune encephalomyelitis Archives of Pathology and Laboratory Medicine 107(11): 600-602
Whitacre, C.C.; Gienapp, I.E.; Orosz, C.G.; Bitar, D.M. 1991: Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy Journal of Immunology 147(7): 2155-2163
Cazzullo, C.L.; Andreola, M.L.; Giordano, F.; Smeraldi, E. 1972: Mechanisms of protection against the experimental allergic encephalomyelitis in the rabbit Acta Neurologica 27(3): 213-219