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Anti-inflammatory activity of some novel 1-[3- (aroylo) ] and one 1-[3- (aryloxy) ]-propyl aminothiazole in correlation with structure and lipophilicity

Hadjipavlou-Litina, D.J.; Geronikaki, A.A.

Arzneimittel-Forschung 46(8): 805-808

1996

ISSN/ISBN: 0004-4172
PMID: 9125283
Document Number: 462569
The effect of some new 1-[3-(aroylo)] and one 1-[3-[aryloxy)]-propyl aminothiazole on inflammation was investigated in the carrageenin-induced mouse paw edema (36-58% edema inhibition). In addition they exhibited significant analgesic activity (55-80.6%) in the writhing test. Their antioxidant activity in vitro using the stable free radical 1.1-diphenyl-2-picrylhydrazyl (DPPH), was determined. Antiproteolytic ability and beta-glucuronidase inhibition have been studied. The tested compounds did not inhibit soybean 12-lipoxygenase. RM values, as an expression of lipophilicity, were determined.

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