Relation between the conformation and antioxidant properties in a series of topochemical analogs of carnosine and carcinine with different N-acyl substitutes
Rozhkova, E.A.; Ogrel', S.A.; Grigor'ev, D.N.; Nebol'sin, V.E.; Zheltukhina, G.A.; Evstigneeva, R.P.
Bioorganicheskaia Khimiia 22(10-11): 838-845
1996
ISSN/ISBN: 0132-3423 PMID: 9036843 Document Number: 462255
To elucidate the influence of the nature of N-acyl substituent on antioxidant properties of carcinine analogs, the corresponding histamine derivatives were synthesized. Antioxidant activity of the compounds prepared was investigated in the Fe(2+)-ascorbate-dependent system of oxidation of the linoleic acid micellar solution. Conformations of carnosine, carcinine, and their analogs were calculated by the molecular mechanics MM+ method. The structural elements and conformations that are preferable for the appearance of antioxidant activity were found.