Synthesis and properties of some new 11-acyl-5,11-dihydro-6H-pyrido [2,3-b] [1,4]-benzodiazepin-6-ones
Decorte, E.; Gratton, G.; Kovac, T.; Mihalić, M.; Comisso, G.; Angeli, C.; Toso, R.; Sunjić, V.
Il Farmaco; Edizione Scientifica 37(12): 787-796
1982
ISSN/ISBN: 0430-0920 PMID: 7152014 Document Number: 186350
The synthesis of 11-acyl-5,11-dihydro-6H-pyrido [2,3-b]-[1,4] benzodiazepin-6-ones (III), (V-IX), is described as well as their spectroscopic characteristics, dipole moments and partition coefficients. The same properties are determined for their N-oxide analogues (X) and (XI), while pharmacological data for some of the above compounds are compared with those of pirenzepin (I), a well known antiulcer drug.
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