Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion
Kan, V.L.; Geber, A.; Bennett, J.E.
Antimicrobial Agents and ChemoTherapy 40(7): 1717-1719
1996
ISSN/ISBN: 0066-4804 PMID: 8807069 Document Number: 461121
The susceptibility of genetically defined Candida glabrata strains to killing by H-2O-2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14-alpha-demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H-2O-2 and neutrophils.
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