In vitro effect of ketoconazole on human neutrophil chemotaxis and Candida albicans killing
Le Moli, S.; Seminara, R.; D'Amelio, R.; Pontesilli, O.; Nisini, R.
Bollettino dell'Istituto Sieroterapico Milanese 62(6): 531-534
1983
ISSN/ISBN: 0021-2547 PMID: 6329246 Document Number: 220682
At 1 micro g/ml ketoconazole showed no distinct synergistic effect on either polymorphonuclear chemotactic or C. albicans killing functions in vitro, but it acted directly on C. albicans cells. In addition, ketoconazole did not demonstrate any chemotactic activity on granulocytes. It is suggested that host cellular defence and ketoconazole exert a parallel, rather than a synergistic, effect.
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