An improved method of preparing protein and peptide probes in mass spectrometry with ionization of division fragments by californium-252 (TOF-PDMS)

Chivanov, V.D.; Zubarev, R.A.; Aksenov, S.A.; Bordunova, O.G.; Eremenko, V.I.; Kabanets, V.M.; Tatarinova, V.I.; Mishnev, A.K.; Kuraev, V.V.; Knysh, A.N.; Eremenko, I.A.; Chivanov, V.D; Zubarev, R.A; Aksenov, S.A; Bordunova, O.G; Eremenko, V.I; Kabanets, V.M; Tatarinova, V.I; Mishnev, A.K; Kuraev, V.V; Knysh, A.N; Eremenko, I.A

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An improved method of preparing protein and peptide probes in mass spectrometry with ionization of division fragments by californium-252 (TOF-PDMS)

Chivanov, V.D.; Zubarev, R.A.; Aksenov, S.A.; Bordunova, O.G.; Eremenko, V.I.; Kabanets, V.M.; Tatarinova, V.I.; Mishnev, A.K.; Kuraev, V.V.; Knysh, A.N.; Eremenko, I.A.

Bioorganicheskaia Khimiia 22(8): 585-588

1996

ISSN/ISBN: 0132-3423

PMID: 8985001

Document Number: 460512

The addition of organic acids (picric, oxalic, citric, or tartaric) to peptide and protein samples was found to significantly increase the yield of their quasi-molecular ions (QMI) in time-of-flight 252Cf plasma desorption mass spectrometry. The yield of the ions depended on the pKa of the acid added.