Radioimmunoassay and chemical ionization/mass spectrometry compared for plasma cortisol determination
Lindberg, C.; Jönsson, S.; Hedner, P.; Gustafsson, A.
Clinical Chemistry 28(1): 174-177
1982
ISSN/ISBN: 0009-9147 PMID: 7055907 Document Number: 191360
We describe a method for determination of cortisol in plasma and urine, based on chemical ionization/mass spectrometry with deuterium-labeled cortisol as the internal standard. The within-run precision (CV) was 2.5-5.7%, the between-run precision 4.6%. Results by this method were compared with those by a radioimmunological method (RIANEN Cortisol, New England Nuclear) for 395 plasma samples. The latter method gave significantly higher (approx. 25%) cortisol values.
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