Chromatin-protective action of the biologically active preparation BTK-8L in tetrachloromethane and chlorophos poisoning
Levitskiĭ, E.L.; Gubskiĭ, I.I.; Primak, R.G.; Goriushko, A.G.; Kholodova, I.D.; Vistunova, I.E.; Marchenko, A.N.
Ukrainskii Biokhimicheskii Zhurnal 68(5): 76-84
1996
ISSN/ISBN: 0201-8470 PMID: 9229857 Document Number: 459495
Results obtained from the study of the interaction between the phytosteroid preparation (BTK-8L) and fractionated rat liver nuclear chromatin under conditions of the tetrachloromethane and chlorophos intoxications are described. It is shown that preventive injection of BTK-8L to the animals has a partial protective effect on transcriptionally active and repressed liver chromatin. This preparation interacts with chromatin histone proteins binding with them and changes the nucleoprotein complex structure as a results of which the chromatin fraction components become less accessible to the damaging action of tetrachloromethane and chlorophos. The BTK-8L protective effect is exhibited on the DNA replication and transcriptional levels under conditions of tetrachloromethane and chlorophos intoxications.