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Squamous cell carcinoma of unknown origin affecting mediastinal lymph nodes

Yodonawa, S.; Mitsui, K.; Akaogi, E.; Onizuka, M.; Ishikawa, S.; Kinoshita, T.; Satoh, Y.; Mitsui, T.

Nihon Kyobu Shikkan Gakkai Zasshi 34(12): 1364-1368

1996

ISSN/ISBN: 0301-1542
PMID: 9022321
Document Number: 456761
A 65-year-old woman was admitted to the hospital because of an abnormal shadow on a chest X-ray film. Chest CT scans showed enlargement of the right mediastinal lymph nodes. However, no primary lesion was detected despite thorough examination. Mediastinoscopic biopsy revealed that the tumor was a lymph-node metastatic lesion of a squamous cell carcinoma of unknown origin. A thoracotomy was done and the mass was completely resected. Radiotherapy was given after the operation. We have followed the patient for 1 year since the operation, but no primary lesion has yet been detected. Metastasis of cancer of unknown origin to hilar or mediastinal lymph nodes is extremely rare, and only 6 cases have been reported previously in the Japanese medical literature.

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