Metastatic squamous cell carcinoma of an unknown primary tumor localized to the neck
Jeremic, B.; Djuric, L.J.; Jevremovic, S.; Stanisavljevic, B.; Milojevic, L.J.; Mijatovic, L.J.
Journal of ChemoTherapy 4(1): 41-45
1992
ISSN/ISBN: 1120-009X PMID: 1403069 Document Number: 388027
68 patients with metastatic squamous-cell carcinoma (SCC) of an unknown primary tumor localized to the neck were treated between 1981 and 1990. There were 11 patients treated with radiotherapy alone, 24 patients treated with surgery and radiotherapy and 33 patients treated wth radiotherapy and chemotherapy. Male to female ratio was 1.9:1 and the median age was 55 years (range, 33 to 71 years). 41 (61%) patients had N3 disease, 18 (26%) patients had N2 disease and 9 (13%) patients had N1 disease. The majority of N3 patients were treated ith radiotherapy + chemotherapy (n = 17) and surgery + radiotherapy (n = 17). The complete response (CR) to radiotherapy + chemotherapy was 73% with 19 patients having no evidence of disease currently. The median survival time (MST) of this group was 34+ months. Of the 35 patients who had surgery and/or radiotherapy, 7 (20%) currently have no evident diseease. The MST of these two groups (combined) was 22 months. patients with N3 disease who received radiotherapy + chemotherapy had a higher CR rate and longer MST when compared with those without chemotherapy.