Protective effects of chrominum on myocardial damage in rats
Xiang, Y.; Song, S.; Bian, J.
Zhonghua Yu Fang Yi Xue Za Zhi 30(4): 225-228
1996
ISSN/ISBN: 0253-9624 PMID: 9388899 Document Number: 456695
To prove the protective effects of trivalent chromium (Cr-3+) on myocardial damage, its ultrastructure and electro-physiological changes were observed in different groups of rats with intraperitoneal injection of normal saline, Cr-3+ and selenium, and injection of adriamycin (ADR) by their tail vein. Results of ultrastructural observations showed nuclear margin of myocardial cells was obscure, cytoplasm became coarse and sparse, mitochondria vacuolar, myocardiofibril loose, broken and lytic in the group treated with ADR, myocardiopathic changes reduced and myocardial filaments arranged in good order in that with Cr-3+ and selenium. QRS complex, Q-T interval, APD-50 and APD-90 in electrocardiograph (ECG) prolonged in the group with ADR and selenium, and no changes were observed in that with Cr-3+. It suggests Cr-3+ and selenium have apparently protective effects on rat's myocardium, and Cr-3+ also can reverse the changes in ECG caused by ADR, which is of importance in prevention and treatment of cardiovascular diseases.