Assessment of the protective effect of vitamin e during development of experimental myocardial damage
Donchenko, H.V.; Kuz'menko, I.V.; Zvaĭd, R.F.
Ukrains'kyi Biokhimichnyi Zhurnal 74(6): 78-82
2002
ISSN/ISBN: 0372-3909 PMID: 12924018 Document Number: 544836
It was shown that creatinphosphokinase activity of blood serum might be used as a criterion for evaluating the level of sparsely distributed damage in myocardium as a result of adrenaline administration. The protective effect of vitamin E under adrenaline-induced myocarditis was studied. The best effect was obtained after triple intramuscular injection of vitamin E before administration of pathological agent. Intravenous injection of the preparation has no benefits over that of intramuscular way of administration. Preventive action of vitamin E shows functioning itself in an increase of the quantity and activity of ubiquinone--the component of electron transport chain in mitochondria.