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Differences in synthesis and degradation of serum proteins in normal and hepatoma-bearing animals

Ove, P.; Coetzee, M.L.; Chen, J.; Morris, H.P.

Cancer Research 32(11): 2510-2518

1972

ISSN/ISBN: 0008-5472
PMID: 4343236
Document Number: 45305
In rats with transplantable hepatoma the serum contained less albumin and more alpha-globulin than usual. Synthesis of serum proteins was similar in tumour-bearing and healthy rats, but there was a lower rate of breakdown of alpha-globulin in the former. Hepatoma tissue was much less able to synthesize albumin than normal liver, and little of the albumin synthesized in hepatomas was released into the blood stream.

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