Comparative study of the nucleotide sequence of the gene for the P/C wild strain or L-16 vaccine strain of measles virus
Markushin, S.G.; Rota, P.; Tikhonova, N.T.; Mamaeva, T.A.; Bellini, V.
Voprosy Virusologii 40(4): 151-154
1995
ISSN/ISBN: 0507-4088 PMID: 7483563 Document Number: 452446
Nucleotide sequences of P/C gene of measles virus IL wild strain and L-16 vaccine strain were compared with the previously reported nucleotide sequence of Edmonston vaccine strain P/C gene. The primary structure of IL strain P/C gene was characterized by two substitutes in 395 (U-C) and 722 (G-A) positions in comparison with the primary structure of a similar Edmonston strain. Nucleotide sequence of L-16 vaccine strain P/C gene differed from the similar sequence of Edmonston vaccine strain by 3 substitutes in 90 (A-G), 399 (U-C), and 448 (U-C) positions. Comparative analysis of nucleotide substitutes in the P/C gene of L-16, IL, and Edmonston strains indicates that the mutations revealed in the L-16 strain P/C gene are not caused by the strain attenuation, but merely reflect the difference between the strains.