Comparison of the nucleotide and deduced amino acid sequences of the structural protein genes of the yellow fever 17DD vaccine strain from Senegal with those of other yellow fever vaccine viruses

Jennings, A.D.; Whitby, J.E.; Minor, P.D.; Barrett, A.D.; Jennings, A.D; Whitby, J.E; Minor, P.D; Barrett, A.D

doi:10.1016/0264-410x(93)90317-q

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Comparison of the nucleotide and deduced amino acid sequences of the structural protein genes of the yellow fever 17DD vaccine strain from Senegal with those of other yellow fever vaccine viruses

Jennings, A.D.; Whitby, J.E.; Minor, P.D.; Barrett, A.D.

Vaccine 11(6): 679-681

1993

ISSN/ISBN: 0264-410X

PMID: 8322493

DOI: 10.1016/0264-410x(93)90317-q

Document Number: 531946

The nucleic acid and deduced amino acid sequences of the structural proteins of the 17DD vaccine strain of yellow fever (YF) virus originating from Senegal are compared with those published for other vaccine strains of YF virus. Even though the 17D-204 and 17DD substrains of 17D diverged at passage 195 of 17D, they show a very high degree of nucleotide (99.5%) and amino acid (99.5%) homology over this region. The sequences are discussed with respect to monoclonal antibodies that can distinguish between 17DD and 17D-204 substrains of YF vaccines.