Organization of the provisional fibronectin matrix: control by products of blood coagulation

Mosher, D.F.

Thrombosis and Haemostasis 74(1): 529-533

1995


ISSN/ISBN: 0340-6245
PMID: 8578520
Document Number: 452007
Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal modules and occurs at specialized cell surface sites. Cellular display of assembly sites is labile and requires that cells be under tension and have functional beta 1 integrins. Lysophosphatidic acid (LPA) an intermediate for de novo lipid biosynthesis and a product of platelet activation, is a powerful serum modulator of fibronectin assembly.

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