Effects of danazol and lynestrenol on serum lipoproteins in endometriosis
Mälkönen, M.; Manninen, V.; Hirvonen, E.
Clinical Pharmacology and Therapeutics 28(5): 602-604
1980
ISSN/ISBN: 0009-9236 PMID: 7438678 DOI: 10.1038/clpt.1980.209Document Number: 451160
The treatment of endometriosis with danazol or lynestrenol decreased cholesterol content of plasma high-density lipoproteins by 50% and 32%. There were simultaneous increases in low-density lipoprotein cholesterol content of 51% and 19%. We suggest that changes induced by lynestrenol are due to progestational activity, while in the case of danazol both antigonadotropic and androgenic activities are involved.