A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis
Cobellis, L.; Razzi, S.; Fava, A.; Severi, F.M.; Igarashi, M.; Petraglia, F.
Fertility and Sterility 82(1): 239-240
2004
ISSN/ISBN: 0015-0282 PMID: 15237024 DOI: 10.1016/j.fertnstert.2003.11.058Document Number: 238166
A danazol-loaded intrauterine device (IUD) containing 300-400 mg of danazol was inserted for 6 months in a group of women (n = 18) (median age 36.6 years; age range: 30 to 46 years) with a histologic diagnosis of endometriosis, referred for recurrent pelvic pain. Dysmenorrhea, dyspareunia, and pelvic pain significantly decreased after the first month, with a persistent effect during the 6 months of IUD insertion. These results show that a danazol-loaded IUD is an effective conservative therapy for patients with endometriosis-related pelvic pain.
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