The effects of hormone implants on serum lipoproteins and steroid hormones in bilaterally oophorectomised women
Farish, E.; Fletcher, C.D.; Hart, D.M.; Azzawi, F.A.; Abdalla, H.I.; Gray, C.E.
Acta Endocrinologica 106(1): 116-120
1984
ISSN/ISBN: 0001-5598 PMID: 6730851 Document Number: 226416
Serum lipoproteins were measured over a period of 6 mo. in 14 oophorectomized women treated with estrogen implants (50 mg/estradiol-17.beta.) and 17 oophorectomized women treated with estrogen/testosterone implants (50 mg estradiol-17.beta., 100 mg testosterone). Both types of implant caused only minimal changes in lipoprotein metabolism. Low density lipoprotein (LDL) cholesterol decreased with both types of implant and high density lipoprotein (HDL) cholesterol rose with the estrogen implants. HDL subfractions were also measured. The estrogen implants caused a transient rise in HDL2 cholesterol levels at 2 mo. and a slower rise in HDL3 cholesterol. The estrogen/testosterone implants had no effect on HDL fractions. Hormone implants did not cause the profound changes in lipoproteins associated with oral hormone therapy.