Effects of ovarian wedge resection (WR) and spironolactone administration on pulsatile LH release and serum steroid hormone levels in women with polycystic ovarian disease
Ohkochi, T.; Tanaka, T.; Oikawa, M.; Sakuragi, N.; Fujimoto, S.; Ichinoe, K.
Nihon Sanka Fujinka Gakkai Zasshi 39(4): 626-632
1987
ISSN/ISBN: 0300-9165 PMID: 3585107 Document Number: 300724
The exact mechanism(s) by which WR induces ovulation in women with PCOD is still uncertain. The aim of this study is to observe the change in sex steroids and pulsatile LH release (pul-LH-R) after WR. Before and either 7.apprx.8 days after the surgery (n=8) or after 30 days of spironolactone treatment (n=4), serum LH levels were measured every 15 min for 2.apprx.4 hours in PCOD women. Sex steroids were radioimmunoassayed before, and 3.apprx.4 and 7.apprx.8 days after WR. Testosterone (T) and androstenedione (A) in 7 women in whom spontaneous ovulation occurred after WR decreased significantly either 3.apprx.4 of 7.apprx.8 days after the surgery (p<0.001). Estrone decreased significantly (p < 0.001) 7.apprx.8 days after the operation. The mean level of LH after WR in the 7 women decreased significantly (p < 0.001). Furthermore, significant decreases both in the mean values of LH pulse amplitude (p < 0.001) and frequency (p < 0.01) were observed after WR. Ovulation occurred after 45 and 58 days of spironolactone administration in 2 PCOD women who showed changes in pul-LH-R and a drop in serum testosterone levels after 30 days of treatment. The data suggested that changes in pul-LH-R and decreased sex steroids after WR seemed to play key roles in the mechanism(s) by which WR induces ovulation.