Morphologic features of immune interrelationships in the feto-placental system in development of a large fetus and in retardation of intrauterine fetal development
Iakovtsova, A.F.; Sorokina, I.V.; Gargin, V.V.
Arkhiv Patologii 57(4): 76-80
1995
ISSN/ISBN: 0004-1955 PMID: 8526763 Document Number: 451110
Indirect criteria of the value of the immune placenta barrier in case of a large foetus are distinguished: relatively small volume of the fibrinoid substance, moderate synthesis by the syncytial epithelium of glucosaminoproteoglycans (GAPG), slight lymphoplasma cell infiltrates with a marked suppressor influence, the lack of antigens HLA = Dr on the trophoblast and formation of the adequate interrelation ship between the immune dependent placental structure and the thymus of the large foetus this allowing to retain the foetus up to 38-40 weeks or even more. In case of delay in the intrauterine foetus development there is a sharp increase of the fibrinoid substance, focal enhancement of GAPG production by the syncytial cells, decrease of the suppressor activity and the appearance in some cases in the trophoblast of antigens to HLA=Dr this being probably the manifestation of a premature exhaustion of compensatory-adaptive reactions in the placenta.