Effects of 4'-chlordiazepam on glycemia and serum lipids in hyperlipidemic rats: interactions with PK 11195 and flumazenil
Cuparencu, B.; Horák, J.
Research Communications in Molecular Pathology and Pharmacology 89(1): 57-66
1995
ISSN/ISBN: 1078-0297 PMID: 7582862 Document Number: 446216
In rats rendered hyperlipidemic by the interperitoneal injection of Triton WR 1339, the administration of 4' - chlorodiazepam, a selective agonist of the peripheral type of benzodiazepine (BZO) receptors evoked significant reductions of serum lipids. PK 11195, a specific antagonist of these receptors, partially inhibited these effects. Flumazenil, a selective antagonist of the central BZD receptors, enhanced the lipid lowering activity of 4'-chlorodiazepam.