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The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein

Madani, A.; Soulier, J.; Schmid, M.; Plichtova, R.; Lermé, F.; Gateau-Roesch, O.; Garnier, J.P.; Pla, M.; Sigaux, F.; Stern, M.H.

Oncogene 10(11): 2259-2262

1995

ISSN/ISBN: 0950-9232
PMID: 7784073
Document Number: 443771
An unusually small (8 kD) protein (p8-MTCP-1) is coded by the putative oncogene MTCP-1 (also called c6.1B), involved in the translocation t(X;14)(q28;q11) associated with some mature T-cell proliferations. Here, we show by subcellular fractionation and by confocal microscopy that this protein is located in the mitochondria. This localization orientates toward a role of p8-MTCP-1 in the mitochondrial metabolism which may be relevant for the oncogenic process.

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