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Interaction between opiate subtypes and serotonin in suppressing noxiously evoked activity of WDR neurons

Nakatani, K.; Kitahata, L.M.; Harada, Y.; Omote, K.; Collins, J.G.; Yuge, O.

Masui. Japanese Journal of Anesthesiology 44(6): 795-799

1995

ISSN/ISBN: 0021-4892
PMID: 7637153
Document Number: 442357
The present study examined interactions between mu and delta opiate subtypes and serotonin. Noxious activity evoked by radiant heat (51 degree C, 8 sec) was extracellularly recorded from single discriminated wide dynamic range (WDR) neurons in decerebrate spinally transected cats. DAGO (mu selective opioid agonist) 1 mu-g or DPDPE (delta selective opioid agonist) 30 mu-g was combined with serotonin (n=6 each) 250 mu-g. The dose of each drug by itself when administered intrathecally produced no suppression of noxiously evoked activity. Although the combination of DAGO and serotonin produced no significant suppression of noxiously evoked activity, DPDPE and serotonin produced significant suppression to 72.8 +- 8.0% (mean +- SEM) of control values (P lt 0.01). Intravenously administered naloxone 0.1 mg reversed the suppression produced by the DPDPE-serotonin combination. Our results suggest that combinations of serotonin and delta selective opiates may be more effective in suppressing noxiously evoked activity than combinations with mu selective opiates. (The present study, carried out at Yale University School of Medicine, USA, was supported by NIH grant in aid NS-09871.)

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