Interaction of thymosin fraction 3 with opiate receptors
Zozulia, A.A.; Khomiakov, I.N.; Bezvershenko, I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(3): 298-300
1986
ISSN/ISBN: 0365-9615 PMID: 3006826 Document Number: 272113
Using the radioreceptor method thymosin fraction 3 was demonstrated to displace 3H-morphine and 3H-naloxone from opiate receptor of crude membrane fraction of the rat brain. The value of EC50 ratio in the presence and absence of 100 mM NaCl seems to indicate that thymosin contains one or several partial agonists of morphine. Furthermore, the peptide nature of these ligands is suggested on the basis of enzymatic treatment data. The possible role of opioid peptides in the realization of thymus endocrine functions is discussed.