Outcome of pregnancy after maternal reinfection with rubella
Morgan-Capner, P.; Miller, E.; Vurdien, J.E.; Ramsay, M.E.
Communicable Disease Report, Review 1(6): R57-R59
1991
ISSN/ISBN: 1350-9349 PMID: 1669775 Document Number: 4406
The precise risk of rubella reinfection in pregnancy remains uncertain despite a three and a half year national study. Our results indicate, however, that congenital infection may be more common than previously supposed. The observed risk of congenital infection after maternal reinfection in the first 12 weeks of pregnancy, obtained by combining the results of this study and two previous reports, is 3/37 (8%), with 95% confidence intervals (CI) from 2% to 22%. The observed risk of fetal infection after primary rubella during the first 12 weeks of pregnancy is over 80%. Exclusion of our two cases in which fetal infection may not have occurred reduces the observed risk to 2.7% (95% CI 0.07% to 14%). Clearly, further studies are required, but they can only be carried out in countries where rubella is still sufficiently prevalent for there to be both the opportunity and the need to determine the outcome of pregnancy after confirmed maternal reinfection.
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