Participation of IL-2 and direct cell cytotoxicity in the modulation of GvH reaction in mice infected with Listeria innocua
Gościcka, T.; Walencka, M.; Szeliga, J.; Bloch, M.; Dziadek, B.
Archivum Immunologiae et Therapiae Experimentalis 43(5-6): 239-245
1995
ISSN/ISBN: 0004-069X PMID: 8744642 Document Number: 440303
Listeria innocua can intensify the development of local GvH reaction in a semiallogeneic system in mice. This phenomenon is observed in (BALB/c times AKR)F1 mice intraperitoneally injected with the live bacteria on the 7th day before the transfer of BALB/c spleen cells. The local GvH reaction develops as strongly as in normal hybrid recipients given the parental cell graft in the presence of exogenous interleukin 2 (IL-2). The development of the reaction is associated with an intensive increase of the direct cytotoxicity of lymph node cells which is also markedly enhanced after the bacteria injection itself IL-2 seems to play a relevant role in the development of local GvH reaction in L. innocua-injected mice.