Cardiotoxicity of parenterally administered iron complexes
Anghileri, L.J.; Maincent, P.; Thouvenot, P.
Arzneimittel-Forschung 45(6): 679-681
1995
ISSN/ISBN: 0004-4172 PMID: 7646569 Document Number: 439519
The role of cell calcium overload in the cardiotoxicity of low molecular weight iron complexes has been studied using 45Ca(2+)-uptake determinations in mice intraperitoneally injected with ferric lactate and ferric-ATP complex. Heart tissue shows a very high increase of 45Ca(2+)-uptake which appears to corroborate the hypothesis of cardiotoxicity by calcium overload. ATP seems to play a role in the degree of iron complex efficiency as cell calcium homeostasis modifier.