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The relation between Behçet's disease and interleukin-1 beta production

Katayama, T.; Tachinami, K.; Ishiguro, M.; Kubota, Y.

Nippon Ganka Gakkai Zasshi 98(2): 197-201

1994

ISSN/ISBN: 0029-0203
PMID: 8109465
Document Number: 439054
Interleukin-1-beta (IL-1-beta) is an inflammatory cytokin. We measured its production in 21 Behcet's disease patients, 4 healthy controls, and 4 sarcoidosis patients, by enzyme-linked immunosorbent assay (ELISA) after stimulation with lipopolysaccharide from peripheral blood monocytes. IL-1-beta production of the posterior segment type was significantly greater (p lt 0.001) than in healthy controls, sarcoidosis patients, and anterior segment type. In all posterior segment type cases, IL-1-beta production in the active period was greater than in the remission period. IL-1-beta production is considered to be related to posterior segment type attacks of Behcet's disease.

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