Activated lymphocytes in glioblastoma: significance for anti-tumoral immunity
Lorusso, L.; Nano, R.; Capelli, E.; Marinu-Aktipi, K.; Benericetti, E.; Giardini, G.; Ceroni, M.
Acta Neurologica 16(4): 198-205
1994
ISSN/ISBN: 0001-6276 PMID: 7856474 Document Number: 437910
Interaction between immune cells and tumoral cells of a case of glioblastoma was studied. Tissue fragments obtained during neurosurgery from different areas of the tumor were examined before and after rIL-2 treatment in vitro. The same morphofunctional type of cells usually activated by rIL-2, which show antitumoral reactivity, was observed both in the glioblastoma imprints and in tumoral fragments cultured with rIL-2. This cytokine stimulated the proliferation of tumor infiltrating lymphocytes in vitro. This preliminary study shows that IL-2 potentiates the differentiation of HMS cells in peripheral blood which probably pass through the blood brain barrier and infiltrate the tumor.