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Evaluation of the mutagenicity of 1-hydrazino-4- (3,5-dimethyl-1-pyrazolyl) pyridazino[4,5-b]indole

Lopez-de Cerain, A.; García, E.; Gullón, A.; Alvarez, T.; Losa, M.J.; Monge, A.

Arzneimittel-Forschung 44(3): 310-312

1994

ISSN/ISBN: 0004-4172
PMID: 8192696
Document Number: 437794
The mutagenic potential of 1-hydrazino-4-(3,5-dimethyl-1-pyrazolyl) pyridazino [4,5-b]indole(A80a, CAS 135561-93-2), a new antihypertensive agent, was investigated in 3 test systems, according to the current EC Guidelines: Ames test with strains TA1535, TA1537, TA98 and TA100, SCE (sister chromatid exchange) test in V79 cells and micronucleus test in Swiss mice. No indications for a mutagenic potential were detected in bacteria and mice; positive results were obtained in eukaryotic cells. The potential for inducing chromosome aberrations in eukaryotic cells will be studied.

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