Evaluation of dimethyl sulfoxide as a solvent in pharmacological experiments
Varma, R.K.; Kaushal, R.; Thomas, G.P.; Junnarkar, A.Y.; Singh, P.P.; Tripathi, R.M.
Indian Journal of Experimental Biology 25(11): 758-760
1987
ISSN/ISBN: 0019-5189 PMID: 3452597 Document Number: 287465
Dimethyl sulfoxide (DMSO), a widely used drug solvent, has been found to possess widespread pharmacological effects including depressant not effect on CNS as evidenced by a decrease in alertness, locomotor activity, body and limb tone and rectal temperature and potentiation of pentabarbitone sleep. A dose-dependent hypotensive effect accompanied by bradycardia was observed in cats. DMSO antagonised the contractions of smooth muscle induced by many agonists. The results indicate that concentrations up to 1 ml/kg for neuropsychopharmacological studies, 0.1 ml/kg for iv administration and 2 ml/l for isolated tissue experiments are safe limits.
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