Differential affinity of anti-Pr-beta-hCG-TT antibodies for hCG and hLH
Shastri, N.; Dubey, S.K.; Raghavan, S.V.; Salahuddin, M.; Talwar, G.P.
Contraception 18(1): 23-34
1978
ISSN/ISBN: 0010-7824 PMID: 679684 DOI: 10.1016/0010-7824(78)90099-9Document Number: 436396
Sera from 4 women immunized with the vaccine Pr-.beta.-hCG-TT . Resolution of Scatchard plots showed the presence of more than 1 population of antibodies in these sera. In each case the Ka of a population of antibodies for binding with hCG were distinctly higher than those for LH. Results indicate the likely presence in .beta.-hCG of determinants and/or conformations immunologically unique to hCG besides common regions. This immunological method represents a development for fertility control by an anti-hCG approach.
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