Differential effect of neonatal injections of anti-mu or anti-delta antibodies on the synthesis of IgM, IgD, IgE, IgA, IgG1, IgG2a, IgG2b, and IgG2c immunoglobulin classes
Bazin, H.; Platteau, B.; Beckers, A.; Pauwels, R.
Journal of Immunology 121(5): 2083-2087
1978
ISSN/ISBN: 0022-1767 PMID: 101595 Document Number: 126227
The effect of neonatally initiated injections of anti-.mu. or anti-.delta. antibodies on Ig lymphoid cells. The IgD suppression confirms that the majority of B lymphoid cells carry IgD receptors during their maturation. The absence of a reaginic immune response indicates that the lack of the IgD receptor can make animals unable to produce primary IgE immune response. The IgD receptor may be considered as an unspecific isotype-positive signal necessary for the majority of the B lymphoid cells to react for the 1st time to a specific antigen stimulation. The differential results of the anti .delta. suppression, contrary to the general suppression obtained by the anti-.mu. inoculation, could be explained by the important requirement by each isotype cell line to be stimulated primarily by an antigen with the help of IgD class receptors.