Clinical significance of anti-beta 2-glycoprotein i antibodies
Amengual, O.; Atsumi, T.; Khamashta, M.A.; Hughes, G.R.
Annales de Medecine Interne 147(Suppl 1): 15-17
1996
ISSN/ISBN: 0003-410X PMID: 8952753 Document Number: 467062
Antiphospholipid antibodies are a heterogeneous group of autoantibodies with clinical importance because of their strong association with thrombotic events. Recent evidence have shown that antiphospholipid antibodies are not directed against phospholipids, as has previously been thought, but are a part of a large family of autoantibodies against phospholipid-binding plasma proteins. So far, one of the most common and best characterized antigenic target is beta 2-glycoprotein I (beta 2-GPI), which plays an important role in the binding of anticardiolipin antibodies (aCLA) to cardiolipin. The detection of anti-beta 2-GPI antibodies by using a simple and rapid ELISA may facilitate the recognition of alpha "pathogenic" alpha aCL in antiphospholipid syndrome.