Indapamide decreases the sensitivity of the rat tail artery to sympathetic actions and the administration of an alpha 2-adrenoreceptor agonist
Medvedeva, N.A.; Zharkova, M.A.; Guseva, A.A.; Medvedev, O.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 57(2): 26-29
1994
ISSN/ISBN: 0869-2092 PMID: 7911366 Document Number: 435509
Indapamide was studied for effects on the constrictor responses of the isolated rat tail artery by using the method of "ex vivo" tail artery perfusion with blood from the awake donor rat. In acute experiments, indapamide, 3 mg/kg i. v., significantly decreased the magnitude of the electrical stimulation-induced constrictor responses of the rat tail artery. They were 77.5% (constrictor responses as % of the initial level of perfusion pressure) before indapamide injection and 37.2 and 30.2% at min 30 and 90 min after indapamide injection, respectively. In chronic experiments (15-day treatment with oral indapamide) there was a significant decrease in constrictor responses to alpha 2-agonist injected.