Structural-functional characteristics of the renal endocrine system after alpha-1 adrenoreceptor blockade
Salikhov, B.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 113(2): 211-214
1992
ISSN/ISBN: 0365-9615 PMID: 1351761 Document Number: 399934
Research Institute of Cardiology, Uzbek Health Ministry Structural and functional peculiarities of the renal juxtaglomerular and interstitial cells were studied after alpha-1-adrenoblockers were used. The endocrine cells were studied after a single and prolonged introduction of the agents. Administration of a single dose of the drugs led to hypergranulation in juxtaglomerular cells thus decreasing their functional activity and release of the granules from the cells. The interstitial cells function intensified. Prolonged administration of alpha-1-adrenoblockers caused a degranulation process in the juxtaglomerular cells and a decrease in their protein-synthetizing structures, namely, renin synthesis, and elevation of synthetic process in the interstitial cells.