The activity of natural killers and K cells and their interferon sensitivity in subjects inoculated against diphtheria and meningococcal infection
Pchelintsev, S.I.; Solokhin, E.V.; Riazantsev, S.V.; Savel'ev, A.P.; Romanov, V.A.; Vasilenko, A.Z.; Tsintsadze, A.G.; Stepanov, A.V.; Denisov, L.A.; Afanas'ev, S.S.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1: 51-55
1994
ISSN/ISBN: 0372-9311 PMID: 8184614 Document Number: 432118
The work deals with the time course of changes in the activity of natural killers, K-cells, their sensitivity to interferon, which reflects, in our opinion, the reserve possibilities of this killer system simultaneously with the development of the specific sensitization of lymphocytes. Significant changes in the cytotoxicity of natural killers, K-cells, have been detected in persons immunized against meningococcal infection, especially in those immunized with meningococcal vaccine introduced in combination with diphtheria toxoid. In this latter group of volunteers even more pronounced sensitization of peripheral blood lymphocytes has been observed than in persons immunized with monopreparations. The results obtained in this investigation indicate that the determination of these cell reactions may be of importance in the evaluation of the effectiveness of immunization.