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Immunological and morphological properties of fibroblasts transformed in vitro. II. The change in the susceptibility of FC3H3 cells to lymphocytes--natural killers and macrophages during their selection for malignancy

Lavrovskiĭ, V.A.; Iurchenko, I.A.; Viksler, V.Kh.

Tsitologiia 26(10): 1181-1185

1984

ISSN/ISBN: 0041-3771
PMID: 6515718
Document Number: 230035
The previous report contained the information on obtaining in vitro continuous cell lines of embryonic fibroblasts of mice of 4 genotypes, including C3H. In this paper, data on the degree of lysis of some derivatives of FC3H3 cells by natural killers and macrophages are given. It was shown that normal cells were not lysed by these effectors unlike cells which overcame Hayflick's limit and got minimum malignancy in vitro. However, it was established that the in vivo selection of cells for high tumorigenicity resulted in the formation of tumor cells resistant to lymphocytes--natural killers and macrophages.

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